Noninvasive monitoring of mouse renal allograft rejection using micro-CT

Noninvasive monitoring of mouse renal allograft rejection using micro-CT

PURPOSE Acute renal graft rejection can only be definitively diagnosed by renal biopsy. However, biopsies carry a risk of renal transplant injury and loss. Micro-CT is widely used in preclinical studies of small animals. Here, we propose micro-CT could noninvasively monitor and evaluate renal location and function in a mouse kidney transplant model. METHODS Orthotopic kidney transplantation w...

Mechanisms of Renal Allograft Rejection

Rejection is the major cause of graft failure, and if the injury to the tubules and glomeruli is severe, the kidney may not recover. It is therefore important to diagnose acute rejection as soon as possible to institute prompt antirejection therapy. Generally, the success with which rejection can be reversed by immunosuppressive agents determines the chance of long-term success of the transplan...

microrna and renal allograft monitoring

Renal allograft rejection: pieces of the puzzle.

Despite a burgeoning literature on renal allograft pathology and rejection diagnosis, there are still many aspects that remain to be resolved. In this issue of JASN, two of these vexing issues are addressed. The first is the finding of isolated arteritis in allograft biopsies, without other diagnostic evidence of acute cellor antibody-mediated rejection (AMR). The other is the identification of...

Mouse kidney transplantation: models of allograft rejection.

Rejection of the transplanted kidney in humans is still a major cause of morbidity and mortality. The mouse model of renal transplantation closely replicates both the technical and pathological processes that occur in human renal transplantation. Although mouse models of allogeneic rejection in organs other than the kidney exist, and are more technically feasible, there is evidence that differe...